6546 LC/Q-TOF and1290 InfinityII HPLC
The 6546 high resolution mass spectrometer accelerates your labs capabilities by enabling comprehensive workflows in metabolomics research, food safety, food authenticity, and environmental screening. With simultaneous high sensitivity, wide dynamic range, high resolution, isotope fidelity, and accurate mass measurements, the resulting high data quality provides the level of confidence you need for fast and simplified data review processes.
With Q-RAI (Quadrupole Resolved All Ions) or All Ions acquisition, food safety screening can now be combined with fragment information for identification, allowing you to conduct target and suspect screening simultaneously. In addition, for metabolomics research, the resolution increase together with broad dynamic range and isotopic fidelity makes the 6546 LC/Q-TOF the ideal platform.
- Quadrupole Time of Flight LC/MS
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Product Details
Features
- Gain confidence at the low and high concentrations with simultaneous delivery of five orders of in-spectrum dynamic range and mass resolution over 60k (for high masses) and over 30k (for low masses)
- Narrow down identification possibilities through sub-ppm mass accuracy and isotope fidelity within 5%
- Experience easy maintenance with vent-free access to ion source and inlet
- Move beyond analytical targeted screening restriction on number of compounds and time-consuming method maintenance with accurate mass spectral libraries for pesticides, veterinary drugs, mycotoxins, extractables and leachables, and water contaminants
- Access metabolomics workflows for profiling, lipidomics, and qualitative flux analysis
- Use the new food authenticity workflow to streamline analysis when testing for product origin or adulteration
Specifications
| In-spectra Dynamic Range |
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| Ion Source |
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| Isotope Fidelity |
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| MS Acquisition Rate |
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| MS Mass Accuracy (negative) |
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| MS Mass Accuracy (positive) |
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| MS Sensitivity (positive) |
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| MS/MS Acquisition Rate |
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| MS/MS Mass Accuracy (negative) |
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| MS/MS Mass Accuracy (positive) |
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| MS/MS Sensitivity (positive) |
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| Polarity Switching Duty Cycle |
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| Quad Resolution (FWHM) |
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| Quadrupole Isolation Mass Range |
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| Software Platform |
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| Supported Software Add-Ons |
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| TOF Mass Range |
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| TOF Mass Resolution (FWHM) |
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| Temperature Mass Stability |
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| Ventless Maintenance |
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Technology
Additional Technology and Software Capabilities for LC/Q-TOF
Agilent partners with selected companies who provide technologies and software that expand the core capabilities of the LC/Q-TOF portfolio. Learn more about additional capabilities and visit the compatibility matrix to see which ones are offered for your LC/Q-TOF!
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How It Works
Applications
Literature
- Key Literature
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Non-Target PFAS Analysis in Dried Blood Spots Using the Agilent 6546 LC/Q-TOF with Profinder and FluoroMatch
This application note demonstrates the use of FluoroMatch Suite for the analysis and identification of per- and polyfluorinated substances (PFAS) using an Agilent1290 Infinity II LC and Agilent 6546 LC/Q-TOF mass spectrometer with iterative exclusion (IE).
- Application Notes
- English
- 13 Mar 2024
- 999.21 KB
Extracellular Flux Analysis and 13C Stable-Isotope Tracing Reveals Metabolic Changes
Combining real-time extracellular flux information with 13C stable‑isotope‑tracing allows greater insight into the mechanism of macrophage activation.
- Application Notes
- English
- 16 Apr 2020
- 733.53 KB
Drug Screening in Whole Blood Using the Agilent 6546 LC/Q-TOF and the LC Screener Tool with Automated Sample Preparation
This application note describes a method for the routine screening of drugs and their related metabolites in whole blood, using the 6546 LC/Q-TOF and Bravo automated linquid handling platform.
- Application Notes
- English
- 18 Mar 2022
- 2.16 MB
- Application Notes
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Support
- Support
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MassHunter Data Acquisition for LC/TOF and LC/Q-TOF Familiarization Guide
This guide teaches you how to use yourMassHunter Data Acquisition for AgilentLC/TOF or LC/Q-TOF system.
- Familiarization Checklists
- English
- 13 Jul 2023
- 4.44 MB
MassHunter Workstation 11.0 for LC/TOF and LC/Q-TOF Installation Guide
This book provides instructions to install theMassHunter Workstation software in theseconfigurations:• Workstation (standalone, no contentmanagement)• Networked Workstation (networked, withcontent management on separate server)
- Installation Guides
- English
- 13 Jul 2023
- 967.69 KB
MassHunter Networked Workstation Functional Design Specifications
This document contains the FunctionalDesign Specifications for your AgilentMassHunter Networked Workstation system.
- Specifications
- English
- 17 Nov 2022
- 13.06 MB
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Didn't find what you need? Contact our support team.
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Customer Testimonials
Nicola Zamboni, PhD
ETH Zurich, Switzerland
"The 6546 is a major advancement compared to previous TOFs, mainly because it combines dynamic range with excellent resolution in all conditions (speed, mass range, intensity). In our hands, the 6546 is going to be a great instrument for challenging applications such as 13C metabolic flux analysis, high-throughput mass spectrometry, and metabolite ID."
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Videos
Training & Events
The PFAS legacy in our urban environment
Per- and polyfluoroalkyl substances (PFAS) are emerging contaminants attracting global scientific and regulatory attention due to their environmental persistence and bioaccumulative properties.
Webinar/Training
Rapid Identification of Unknowns in Blackwater Using LC/QTOF-MS/MS
Liquid chromatography/quadrupole time-of-flight mass spectrometry with data dependent and independent analysis was used to identify target, suspect, and unknown compounds in aqueous leachate of wildfire ash and blackwater samples from the largest wildfire in Colorado history.
Webinar/Training
High-throughput LC-MS analysis to systematically map gut microbiome drug metabolism
Individuals vary widely in their drug responses, which can be dangerous and expensive due to significant treatment delays and adverse effects.
Webinar/Training
News
Agilent Announces Inspirational LC/TQ and LC/Q-TOF Mass Spectrometry Solutions at ASMS 2023
Agilent Technologies announced two new liquid chromatography mass spectrometry systems (LCMS), the Agilent 6495D LC/TQ and the Agilent Revident LC/Q-TOF. Facilitating the high-end performance of the Revident LC/Q-TOF, Agilent is also announcing the new Agilent MassHunter Explorer Profiling software and the new Agilent ChemVista library manager software.
- 05 Jun 2023
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