6530 QTOF LC/MS for accurate mass spectrometry (2024)

6530 QTOF LC/MS for accurate mass spectrometry (1)

Raise your analysis to a new level with the Agilent 6530 Q-TOF mass spectrometer. Full MS spectra followed by MS/MS or All Ions acquisition make this instrument suitable for applications in the pharmaceutical industry as well as life sciences and governmental agencies. Accurate mass spectrometry enables you to gain more confidence in your analysis compared to unit resolution instrumentation.

The 6530 Q-TOF LC/MS delivers the power of accurate-mass mass spectrometry, so you can be fully confident of your data. All software workflows from our high-end and mid-range instruments are fully compatible with the 6530, giving you the most powerful access to your data and research possible. The demonstrated robustness of the 6530 will keep your lab up to speed.

  • Quadrupole Time of Flight LC/MS

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6530 QTOF LC/MS for accurate mass spectrometry (3)

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Product Details

Features

  • Mass accuracy within 2 ppm gives you complete confidence in your analysis.
  • Powerful Agilent Jet Stream source enables you to uncover low level components.
  • Wide in-spectrum dynamic range facilitates simultaneous measurement of minor components in the presence of intense background interferences.
  • The latest developments in Agilent Infinity II UHPLC, 2D-LC, SFC, and even GC-APCI chromatographic interfaces give you blazing fast acquisition speed.
  • Powerful MassHunter software provides the latest software capabilities for profiling, characterizing, identifying, and quantifying compounds in complex mixtures via high-definition MS and MS/MS.
  • Untargeted screening and quantitation using Agilent’s All Ions MS/MS technique.

Specifications

In-spectra Dynamic Range
  • 5 Orders
Ion Source
  • Dual-AJS
  • Dual-ESI
  • APCI
  • MultiMode (ESI+APCI)
  • GC/APCI
  • NanoESI
MS Acquisition Rate
  • 50 spectra/second
MS Mass Accuracy (positive)
  • <2 ppm RMS
MS Sensitivity (positive)
  • S/N (RMS) > 200:1. Measured with 1pg reserpine on column
MS/MS Acquisition Rate
  • 50 spectra/second
MS/MS Mass Accuracy (positive)
  • <3 ppm RMS
MS/MS Sensitivity (positive)
  • S/N (RMS) > 500:1. Measured with 1pg reserpine on column
Polarity Switching Duty Cycle
  • 1 s
Quad Resolution (FWHM)
  • 1.3 Da (autotune)
Quadrupole Isolation Mass Range
  • m/z 20-4000
Software Platform
  • MassHunter
Supported Software Add-Ons
  • MassHunter BioConfirm
  • MassHunter VistaFlux
  • Mass Profiler Professional
  • Classifier
  • Lipid Annotator
TOF Mass Range
  • m/z 20-20,000
TOF Mass Resolution (FWHM)
  • > 10,000 at m/z 118 independent of acquisition rate
  • > 20,000 at m/z 1522 independent of acquisition rate
Temperature Mass Stability
  • <1 ppm / 3 °C

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Technology

Additional Technology and Software Capabilities for LC/Q-TOF

Agilent partners with selected companies who provide technologies and software that expand the core capabilities of the LC/Q-TOF portfolio. Learn more about additional capabilities and visit the compatibility matrix to see which ones are offered for your LC/Q-TOF!

Learn More

Literature

Key Literature

Long-Term Robustness of Agilent LC/Q-TOF Systems for Untargeted Lipidomics

Long-term robustness of Agilent LC/Q-TOF systems for untargeted lipidomics in plasma cohort studies for clinical research in type 1 diabetes mellitus.

  • Application Notes
  • English
  • 25 Oct 2023
  • 346.39 KB
  • PDF

Analysis of Antibody Drug Conjugates Using SEC and Mass Spectrometry

Analysis of an mAb (trastuzumab) and an ADC (trastuzumab emtansine) by size exclusion chromatography with online mass spectrometry (SEC-MS)

  • Application Notes
  • English
  • 22 Nov 2017
  • 952.95 KB
  • PDF

Detection and Identification of Extractable Compounds from a Drug Container Closure System

Extractables analysis using high resolution LC/MS system and sample comparison using Agilent Mass Profiler Software.

  • Application Notes
  • English
  • 15 Oct 2015
  • 1.24 MB
  • PDF
Application Notes
Brochures
Flyers
Posters
Technical Overviews
White Papers

Support

Support

MassHunter Data Acquisition for LC/TOF and LC/Q-TOF Familiarization Guide

This guide teaches you how to use yourMassHunter Data Acquisition for AgilentLC/TOF or LC/Q-TOF system.

  • Familiarization Checklists
  • English
  • 13 Jul 2023
  • 4.44 MB
  • PDF

MassHunter Workstation 11.0 for LC/TOF and LC/Q-TOF Installation Guide

This book provides instructions to install theMassHunter Workstation software in theseconfigurations:• Workstation (standalone, no contentmanagement)• Networked Workstation (networked, withcontent management on separate server)

  • Installation Guides
  • English
  • 13 Jul 2023
  • 967.69 KB
  • PDF

MassHunter Networked Workstation Functional Design Specifications

This document contains the FunctionalDesign Specifications for your AgilentMassHunter Networked Workstation system.

  • Specifications
  • English
  • 17 Nov 2022
  • 13.06 MB
  • PDF
FAQs
Quick Reference Guides
Site Preparation Checklists
Supplemental Information
User Manuals

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Training & Events

Agilent University

Develop skills and improve lab productivity with a wide variety of learning options from Agilent Education.

Location:

Training is available online

Events

News

Agilent Announces Inspirational LC/TQ and LC/Q-TOF Mass Spectrometry Solutions at ASMS 2023

Agilent Technologies announced two new liquid chromatography mass spectrometry systems (LCMS), the Agilent 6495D LC/TQ and the Agilent Revident LC/Q-TOF. Facilitating the high-end performance of the Revident LC/Q-TOF, Agilent is also announcing the new Agilent MassHunter Explorer Profiling software and the new Agilent ChemVista library manager software.

  • 05 Jun 2023

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6530 QTOF LC/MS for accurate mass spectrometry (2024)
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